New research: Cannabinoid-loaded microparticles inhibit brain cancer cell growth in mice
Researchers in Spain have found that the local administration of microparticles loaded with tetrahydrocannabinol (THC) and cannabidiol (CBD) – the two major ingredients of marijuana – reduced tumor growth in a mouse model of human glioma (brain cancer).
These novel microparticles are small spheres (~50 microns in diameter) in which the therapeutic molecules (in this case, the anti-cancerous molecules THC and CBD) are encapsulated in a biodegradable polymer. Microparticle drug carrier/delivery systems offer the benefits of controlling drug release, improving therapeutic effects, prolonging biological activity, and decreasing administration frequency.
The researchers found that when microencasulated THC and CBD was directly administered to human glioma cancer cells grafted to mice, it decreased cell proliferation, decreased angiogenesis (the penetration of blood vessels into tumors which promote metastasis), and enhanced apoptosis (the programmed death of cells).
The researcher’s findings strongly support that microencapsulation could be a promising strategy to optimize the use of cannabinoids as anticancer agents.
Hernan Perez de la Ossa D, Lorente M, et al. Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. PLoS One. 2013; 8(1): e54795.